Partners

Hans C. HENNIES:


Hans C. Hennies obtained a PhD from the Freie Universität Berlin (Germany) on molecular studies of genetic keratinization disorders under supervision of Profs. André Reis and Karl Sperling. After research stays in London (UK) and at the Max Delbrück Center for Molecular Medicine (Berlin, Germany) he became a principal investigator at the Cologne Center for Genomics (CCG), University of Cologne (Germany). He is a co-founder and vice chairperson of the German Network for Ichthyoses and head of the Center for Dermatogenetics, which runs laboratories at the Cologne Center for Genomics and the Innsbruck Medical University (Innsbruck, Austria). Major research interests include the elucidation of the molecular basis for genetic skin and hair diseases. The team has focused on mechanisms involved in epidermal differentiation and the formation of the epidermal barrier, and they have found several factors contributing to these processes using genomics approaches to identifying genes and mutations. Recently they have used primary fibroblasts and keratinocytes to develop full-skin models for genetic diseases, in particular presenting with congenital ichthyosis, and extended these approaches to using pluripotent stem cells for modelling more complex disorders.   Pubmed

Daniel ABERDAM:

Daniel Aberdam lab


Prof. Daniel Aberdam completed his first degrees at Pierre and Marie Curie University (Paris, France) and his PhD at the Weizmann Institute (Israel) on the oncogenic potential of homeotic genes under the supervision of Prof. Leo Sachs. He currently holds the position of INSERM Director of Research at INSERM U976 (Paris Diderot University, France) and the INSERTECH laboratory (Technion, Israel). His scientific interests focus on epidermal gene regulation and skin physiopathology. Recenty, his group developed strategies to recapitulate in vitro embryonic skin development derived from pluripotent (embryonic and induced reprogrammed) stem cell lines and from patient reprogrammed cells. The current projects developed by his teams are centered around the use of pluripotent stem cells as cellular models for skin, cornea and cardiac pathophysiology.  Pubmed




Eli SPRECHER:


Education

PhD, Hebrew University, Jerusalem
MD, Hebrew University, Jerusalem
Post-doctoral fellowship, Thomas Jefferson University, Philadelphia, USA

Interests

Genetics of skin diseases
Pediatric dermatology

Clinical Experience

2007-2008 Director, Center for Translational Genetics, Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Haifa, Israel
2009-  Affiliated member, Department of Human Molecular Genetics & Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel
2010-  Professor of Dermatology, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

Publications

More than 150 professional scientific publications

For a listing of recent publications, refer to PubMed

Membership in Professional Societies

American Society of Genetics
Israel Society of Dermatological and Venereology
Israel Society for Genetics
Society of Investigative Dermatology (USA)
American Academy of Dermatology

Additional activities

2007-  Associate Editor, Journal of Investigative Dermatology
2006-  Section Editor, British Journal of Dermatology
2010-  Chairman, Examination Board in Dermatology and Venereology, Scientific council

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Caterina MISSERO:


Dr. Caterina Missero trained first at Yale University under the supervision of Dr. G.P. Dotto, and then at Harvard University as an Instructor in Dermatology. She is currently an independent investigator at the Center for Genetic Engineering (CEINGE; www.ceinge.unina.it) at the Federico II University in Napoli, Italy. Her research focuses on the transcriptional mechanisms and genetic pathways required for normal skin development, in inherited and acquired skin diseases. Using primary keratinocytes derived from human and mouse skin and mouse genetic models, she is investigating how epithelial cells in the skin establish unique programs of gene expression. Her team has been dissecting the molecular pathways controlled by the transcription factor p63, a master regulator of stratified epithelia. Recently a mouse model for AEC syndrome, a genetic disorder caused by mutation in the p63 gene, has been generated in her laboratory and has been used to study the pathogenetic mechanisms of the disease. Pubmed