Links to Web sites

TOOLS & METHODS:

Generation of human iPS from skin biopsies

Generation of human iPS from hair follicles

Epidermal differentiation of human iPS (from DA) pdf



Publications partially funded by SkinDev consortium:


1. Eckl KM, Tidhar R, Thiele H, Oji V, Hausser I, Brodesser S, Preil ML,Onal-Akan A, Stock F, Müller D, Becker K, Casper R, Nürnberg G, Altmüller J, Nürnberg P, Traupe H, Futerman AH, Hennies HC. Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length. J Invest Dermatol. 2013 133(9):2202-11. 


2. Günschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Brüning JC, Niessen CM. Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition. Dev Cell. 2013 26(2):176-87. 


3. Ferone G, Mollo MR, Thomason HA, Antonini D, Zhou H, Ambrosio R, De Rosa L, Salvatore D, Getsios S, van Bokhoven H, Dixon J, Missero C. p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet. 2013 22(3):531-43.


4. Shalom-Feuerstein R, Serror L, Aberdam E, Müller FJ, van Bokhoven H, Wiman KG, Zhou H, Aberdam D, Petit I. Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET. Proc Natl Acad Sci U S A. 2013 110(6):2152-6. 


5. T. Goldsmith, O. Eytan, L. Magal, M. Solomon, S. Israeli, E. Warshauer, M. Grafi-Cohen, D. Aberdam, H. van Bokhoven, J.H. Zhou, O. Sarig, E. Sprecher,  J. Nousbeck. A novel mutation in TP63 causing a mild ectodermal dysplasia phenotype. J. Invest. dermatol. 134(8):2277-80.


6. Antonini D, Sirico A, Aberdam E, Ambrosio R, Campanile C, Fagoonee F, Aberdam D, Brissette JL and Missero C. 2015. A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms. Nucl Ac Res. 2015 Jan 7. [Epub ahead of print]


7. Eckl KM, Weindl G, Ackermann K, Küchler S, Casper R, Radowski MR, Haag R, Hennies HC*, Schäfer-Korting M (*corresponding). Increased cutaneous absorption reflects impaired barrier function of reconstructed skin models mimicking keratinisation disorders. Exp Dermatol 2014 23:286-288.

 

8. Alnasif N, Zoschke C, Fleige E, Brodwolf R, Boreham A, Rühl E, Eckl KM, Merk HF, Hennies HC, Alexiev U, Haag R, Küchler S, Schäfer-Korting M. Penetration of normal, damaged and diseased skin - An in vitro study on dendritic core-multishell nanotransporters. J Control Release 2014 185:45-50.


9. Mollo MR, Antonini D, Mitchell K, Fortugno P, Costanzo A, Dixon J, Brancati F,

Missero C. p63-dependent and independent mechanisms of nectin-1 and -4 regulation in the epidermis. Exp Dermatol. 2014 Nov 12.[Epub ahead of print]


10. Johnson JL, Koetsier JL, Sirico A, Agidi AT, Antonini D, Missero C, Green KJ. 

The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. J Invest Dermatol. 2014 Aug;134(8):2154-62.


11. Warshauer E, Samuelov L, Sarig O, Vodo D, Bindereif A, Kanaan M, Gat U, Fuchs-Telem D, Shomron N, Farberov L, Pasmanik-Chor M, Nardini G, Winkler E, Meilik B, Petit I, Aberdam D, Paus R, Sprecher Eli and Nousbeck J. (2015) RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63. Exp. Dermatol., in press.